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severe hemophilia factor 8 deficiencyfactor eight deficiencyfactor 8 deficiency diagnosisfactor 8 deficiency and pregnancyacquired factor 8 deficiencyblood factor 8 deficiencyfactor 8 deficiency and surgeryfactor 8 deficiency in femalesclotting factor 8 deficiencyeffects of hemophiliapathophysiology of hemophiliahemophilia disorder