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myeloma relapse prognosismultiple myeloma recurrence prognosismultiple myeloma relapse symptomsprognosis for multiple myelomarelapsed refractory multiple myelomacancer multiple myeloma prognosismyeloma relapse symptomsmultiple myeloma stage 3 prognosismultiple myeloma relapse raterelapsed refractory myelomamyeloma relapse criteriasymptomatic multiple myeloma